In 2006 the SC430 was entered in the Autobacs Super GT race series in the GT500 class. Extensively modified from the factory car, the engine used is a modified version of the SC430's 3UZ-FE V8 that was also used in the Toyota Supra GT500 from its previous years.

The new SC430 based race cars were immediately competitive with former GT500 champion Juichi Wakisaka and no.2 driver Andre Lotterer driving the Open Interface TOM's SC to victory at the opening round at Suzuka giving the SC430 its first victory on its debut race.

Juichi Wakisaka and Andre Lotterer also won the GT500 Class championship during the same year. In 2007, Lexus SC fully replaces the Supra in the Toyota side, a Zent Cerumo SC430 driven by Yuji Tachikawa was victorious in the GT500 opening round race.